John F. Kennedy was an American politician who served as the President of the United States during the early 1960s, holding this office until his assassination in 1963. He was the brother of Robert F. Kennedy.
President Kennedy was assassinated in Dallas on 22 November 1963. His wife, Jacqueline Kennedy, was seated next to him in the car they were travelling in. The ninth incarnation of the Doctor was present in the crowd at the time. (DW: "Rose"; "Web of Lies") His assassination involved a school book depository. ("Web of Lies") The seventh incarnation of the Doctor once claimed that the coming of the Nemesis, whose orbit returns it to the Earth every 25 years, was the reason for Kennedy's assassination. (DW: "Silver Nemesis")
By 2004, a photograph depicting Kennedy shortly before his assassination could be found in the Washington public archive. A copy of the photograph that was in the possession of Clive Finch was shown to Rose Tyler in March 2005. (DW: "Rose")
Upon hearing of how many attempts there had been to assassinate Queen Victoria by 1879, Rose Tyler told the Doctor that she had always associated the word "assassination" with Kennedy. (DW: "Tooth and Claw")
The first episode of "An Unearthly Child", the first ever Doctor Who serial, aired one day after Kennedy's assassination. Consequently, the broadcast was overshadowed by the news coverage of his death, which delayed the beginning of the program by eighty seconds. At the time, "The Mutants" was in the production of its second episode and the news of Kennedy's death created a general atmosphere of grimness for the rest of the day's filming.